Transcriptional analysis of prsA and vraTS regulatory system in methicillin resistant Staphylococcus aureus against oxacillin stress

D Bhowmik, BJ Das, M Hazarika, DD Chanda… - Indian Journal of …, 2022 - Elsevier
… both hospital and community-acquired infections. Methicillin … and also requires the two-component
regulators, namely vraS … aureus strain N315 which is null mutant of vraS/vraR showed …

NH125 Sensitizes Staphylococcus aureus to Cell Wall-Targeting Antibiotics through the Inhibition of the VraS Sensor Histidine Kinase

S Bhattarai, L Marsh, K Knight, L Ali… - Microbiology …, 2023 - Am Soc Microbiol
Staphylococcus aureus utilizes the two-component regulatory system VraSR to receive
and … for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and …

[HTML][HTML] VraSR Regulatory System Contributes to the Virulence of Community-Associated Methicillin-Resistant Staphylococcus aureus (CA-MRSA) in a 3D-Skin …

N Barua, Y Yang, L Huang, M Ip - Biomedicines, 2021 - mdpi.com
aureus (SA) expresses a wide range of virulence factors regulated by the Two-component
regulatory systems (… VraS and VraR TCR is required for resistance to cell wall antibiotics, eg, …

[HTML][HTML] Antibacterial activities and action mode of anti-hyperlipidemic lomitapide against Staphylococcus aureus

Y Zhang, Y Zhang, C Chen… - BMC …, 2022 - bmcmicrobiol.biomedcentral.com
… of the predominant causes of community-acquired or hospital-… Therefore, it is necessary for
clinicians to put attention to the … the VraS/VraR two-component regulatory system participated …

[HTML][HTML] Antimicrobial Resistance: Two-Component Regulatory Systems and Multidrug Efflux Pumps

GV De Gaetano, G Lentini, A Famà, F Coppolino… - Antibiotics, 2023 - mdpi.com
… the requirement of a phosphorylated response regulator [144]. … evgA up-regulation does not
determine resistance to oxacillin, … both nosocomial and community-acquired infections and is …

Regulation of the Sae two-component system by branched-chain fatty acids in Staphylococcus aureus

A Pendleton, WS Yeo, S Alqahtani, DA DiMaggio Jr… - Mbio, 2022 - Am Soc Microbiol
… virulence regulatory systems—the Agr quorum sensing system … The Sae TCS is an important
virulence regulator which … , VraS transcript number, required for oxacillin resistance (52), …

β-Lactamase Suppression as a Strategy to Target Methicillin-Resistant Staphylococcus aureus: Proof of Concept

PM Thomas, MA Deming, A Sarkar - ACS omega, 2022 - ACS Publications
… (8) Community-acquired MRSA infections are widespread now … two central pathways controlling
oxacillin resistance: A eukaryotic… A close-up view of the VraSR two-component system. A …

Adaptive laboratory evolution and independent component analysis disentangle complex vancomycin adaptation trajectories

A Fait, Y Seif, K Mikkelsen, S Poudel… - Proceedings of the …, 2022 - National Acad Sciences
… Infections with methicillin-resistant Staphylococcus aureus (… to be regulated by some of the
mutated two-component systems … cell wall metabolism and transcriptional regulatory systems. …

Pyrimidine-2-amines increase susceptibility of methicillin-resistant Staphylococcus aureus to penicillin G

P Thomas, M Deming, A Sarkar - 2022 - chemrxiv.org
… penicillin G useless against methicillin-resistant Staphylococcus aureus (MRSA). … VraS/VraR
two-component regulatory system required for oxacillin resistance in community-acquired

A benzoxazolylurea inhibits VraS and enhances antimicrobials against vancomycin intermediate-resistant Staphylococcus aureus

A Sarkar, MH Abdelaziz, EP Heckler, L Ali… - bioRxiv, 2023 - biorxiv.org
… The VraS/VraR two-component regulatory 282 system required for oxacillin resistance in
community-acquired methicillin-resistant 283 Staphylococcus aureus. FEMS Microbiol Lett 262:…